Saccharomyces cerevisiae Pathway/Genome Database

YeastCyc is a Pathway/Genome Database of the model eukaryote Saccharomyces cerevisiae S288c. In addition to genomic information, the database contains metabolic pathway, reaction, enzyme, and compound information, which has been manually curated from the scientific literature. The database was generated in 2002 by the SGD project using SRI's Pathway Tools software, and benefited from significant curation by SGD. In 2012 the database was transferred to SRI International, where it is curated by curators from the SRI Bioinformatics Research Group, and from the Boyce Thompson Institute. That curation process includes periodic updates to the metabolites, reactions and pathways from the current version of MetaCyc to ensure compatibility with other members of the MetaCyc family of databases. YeastCyc has been curated from 2,100 publications. For details on recent curation, please click here.

YeastCyc is part of the larger BioCyc collection of thousands of Pathway/Genome Databases for sequenced genomes. Click "change organism database" in the upper right corner to explore the available databases.

Subscriptions are now required to access BioCyc. For more information on obtaining a subscription, click here. Why the transition to subscriptions?

User Guide >>
  • Cellular Overview

    Cellular Overview image generated by Pathway Tools.

    Explore Saccharomyces cerevisiae Metabolic Maps

    The Cellular Overview enables you to browse through zoomable metabolic map diagrams that are customized to each BioCyc organism.

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  • E. coli, bacteria, cryo FIB-SEM, dotted with silver nanoparticles

    BioCyc iOS App for iPhone/iPad

    Saccharomyces cerevisiae on your iPhone and iPad

    Have you ever wanted to quickly find out what is known about a gene, protein or pathway that was just mentioned in a talk or on a poster? Download the free BioCyc iPhone app to browse BioCyc on the go! Try the iPad version as well.

    Download Here
  • Route Search Diagram


    RouteSearch: Search for Paths through the Metabolic Network

    Search for lowest-cost paths through the metabolic network of the selected organism. Or, design lowest-cost pathways to novel compounds by adding reactions from MetaCyc.

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  • Saccharomyces cerevisiae Metabolic Modeling with MetaFlux

    Build quantitative metabolic flux models using the MetaFlux metabolic modeling component of Pathway Tools.

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  • Multiple Sequence Alignment Image

    Multiple Sequence Alignment results generated by Pathway Tools using MUSCLE.

    Multiple Sequence Alignments

    You can now generate multiple sequence alignments for genes or proteins - within a genome or between genomes.

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  • SmartTable display generated by Pathway Tools.

    Metabolomics Data Analysis

    Multiple tools are available in this website for metabolomics data analysis.

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  • Cellular Overview Omics Viewer image generated by Pathway Tools.

    Gene Expression Data Analysis

    Multiple tools are available in this website for analysis of gene expression data.

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  • Multi-Genome Browser

    Multi-organism Genome Browser image generated by Pathway Tools.

    Saccharomyces cerevisiae Comparative Genome Analysis

    Multiple comparative analysis tools are available in this website.

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  • BioCyc Database Collection

    BioCyc Database Collection

    The Components of BioCyc

    BioCyc is a database collection. Tier-1 databases such as EcoCyc and HumanCyc are the most highly curated. Most BioCyc databases have been computationally derived from MetaCyc.

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This site includes extensive retrieval, visualization and analysis tools:

This website is part of the BioCyc database collection of 18025 microbial genomes.

    Getting Started

      Retrieve the sequence of your favorite gene:
      1. Select your genome of interest by clicking "change organism database" at the top-right of this page.
      2. Type the gene name into the "Quick Search" box at the top right of this page.
      3. Click on "Gene Search".
      4. In the "Operations" menu on the right side, click on the "Nucleotide Sequence" link to retrieve the sequence from the start to the stop codon.

      New to this site? Take the guided tour of the Web site or try the Quick Search box at top right.

Video Tutorials

The BioCyc video series introduces users to the basic and advanced features of the BioCyc website and the Pathway Tools software. A complete list of video tutorials is available on the BioCyc webinars page.

This video introduces the site and the BioCyc collection of thousands of Pathway/Genome Databases and covers:

  • BioCyc site contents, including EcoCyc, MetaCyc, and our extensive database collection
  • How to search, browse, and find what you need in the BioCyc collection
  • How we represent metabolism, transcription, and all their parts